The pace of the sequencing and computational assembly of novel reference genomes is
accelerating. Though DNA sequencing technologies and assembly software tools continue …

As plentiful high-quality genome assemblies have been accumulated, reference-guided
genome assembly can be a good approach to reconstruct a high-quality assembly. Here, we …

Biological and biomedical research is increasingly conducted in large, interdisciplinary
collaborations to address problems with significant societal impact, such as reducing …

Motivation Optical mapping data is used in many core genomics applications, including
structural variation detection, scaffolding assembled contigs and mis-assembly detection …

Historically, short-read sequencing has been the preferred method for sequencing targeted
gene panels, exomes, and genomes in the clinical laboratory. However, other technologies …

Motivation Optical maps are high-resolution restriction maps (Rmaps) that give a unique
numeric representation to a genome. Used in concert with sequence reads, they provide a …

Genome wide optical maps are high resolution restriction maps that give a unique numeric
representation to a genome. They are produced by assembling hundreds of thousands of …

Deciphering genetic information through next-generation sequencing (NGS) is considered
as the basic platform to unveil in details of an organism. However, as it produces short reads …

Reducing the cost of sequencing genomes provided by next-generation sequencing
technologies has greatly increased the number of genomic projects. As a result, there is a …

A key problem in processing raw optical mapping data (Rmaps) is finding Rmaps originating
from the same genomic region. These sets of related Rmaps can be used to correct errors in …