Abstract The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is
associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) …

Context Continuing advances in genotyping technologies and the inclusion of DNA
collection in observational studies have resulted in an increasing number of genetic …

A clear and thorough introduction to meta-analysis, the process of synthesizing data from a
series of separate studies The first edition of this text was widely acclaimed for the clarity of …

MTHFR polymorphism testing is frequently ordered by physicians as part of the clinical
evaluation for thrombophilia. It was previously hypothesized that reduced enzyme activity of …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Abstract The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the
folate metabolism pathway, the byproducts of which are involved in the remethylation of …

Polymorphisms in folate pathway genes may influence the susceptibility to acute
lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) …

Megaloblastic anaemia is usually due to deficiency of vitamin B12 (B12, cobalamin) or
folate. Both deficiencies impair DNA synthesis by reducing the supply of deoxythymidine …

Pharmacogenetics represents an exciting, new promising tool for the individualisation of
therapy. Several genetic polymorphisms and haplotypes have been considered in an …

Objective We evaluated the interaction of serum folate and vitamin B12 with
methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on the risk of first ischemic …