The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and
their inherited and spontaneous mutations give rise to keratinopathies. For example …

Fatty liver disease is a multifactorial world-wide health problem resulting from a complex
interplay between liver, adipose tissue and intestine and initiated by alcohol abuse …

Yes-associated protein 1 (YAP1) is a transcriptional coactivator in the Hippo signaling
pathway. Increased YAP1 activity promotes the growth of tumors, including that of colorectal …

Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support
strong adhesion, help barrier formation, and regulate growth. The mechanisms by which …

While it might be expected that fidelity is always perfect in mapping from the DNA triple code
to the specific amino acid it codes for, multiple studies have shown that this is not the case [1 …

Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic
pathway that lead to accumulation of heme precursors. Consequences of porphyria include …

Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis
and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are …

ABSTRACT Introduction: Protein sequestosome 1/p62 (p62) plays a crucial role in vital
complex and interacting signaling pathways in normal and neoplastic cells. P62 is involved …

Mallory‐Denk bodies (MDBs) are protein aggregates consisting of ubiquitinated keratins
8/18 (K8/K18). MDBs are characteristic of alcoholic and nonalcoholic steatohepatitis (NASH) …

Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired
survival pathways contribute to liver injury caused by hepatotoxins. We investigated the role …