SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

AA Rabaan, SH Al-Ahmed, R Sah, R Tiwari… - Annals of Clinical …, 2020 - Springer
A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19),
first detected in Wuhan City, Hubei Province, China, which has taken a catastrophic turn with …

COVID‐19: A systematic review and update on prevention, diagnosis, and treatment

H Aghamirza Moghim Aliabadi… - MedComm, 2022 - Wiley Online Library
Since the rapid onset of the COVID‐19 or SARS‐CoV‐2 pandemic in the world in 2019,
extensive studies have been conducted to unveil the behavior and emission pattern of the …

Molecular simulations suggest vitamins, retinoids and steroids as ligands of the free fatty acid pocket of the SARS‐CoV‐2 Spike protein

DK Shoemark, CK Colenso, C Toelzer… - Angewandte …, 2021 - Wiley Online Library
We investigate binding of linoleate and other potential ligands to the recently discovered
fatty acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular …

Combination of Hua Shi Bai Du granule (Q-14) and standard care in the treatment of patients with coronavirus disease 2019 (COVID-19): a single-center, open-label …

J Liu, W Yang, Y Liu, C Lu, L Ruan, C Zhao, R Huo… - Phytomedicine, 2021 - Elsevier
Objective To evaluate the efficacy and safety of Hua Shi Bai Du Granule (Q-14) plus
standard care compared with standard care alone in adults with coronavirus disease …

Computational identification of potential anti-inflammatory natural compounds targeting the p38 mitogen-activated protein kinase (MAPK): Implications for COVID-19 …

SO Asiedu, SK Kwofie, E Broni, MD Wilson - Biomolecules, 2021 - mdpi.com
Severely ill coronavirus disease 2019 (COVID-19) patients show elevated concentrations of
pro-inflammatory cytokines, a situation commonly known as a cytokine storm. The p38 …

Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development

XH Liu, T Cheng, BY Liu, J Chi, T Shu… - Frontiers in …, 2022 - frontiersin.org
COVID-19 caused by SARS-CoV-2 has raised a health crisis worldwide. The high morbidity
and mortality associated with COVID-19 and the lack of effective drugs or vaccines for SARS …

Computational simulations identified marine-derived natural bioactive compounds as replication inhibitors of SARS-CoV-2

V Kumar, S Parate, S Yoon, G Lee… - Frontiers in microbiology, 2021 - frontiersin.org
The rapid spread of COVID-19, caused by the novel severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a worldwide health emergency. Unfortunately, to date, a …

[HTML][HTML] Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line

AB Coffin, E Dale, E Doppenberg… - Frontiers in Cellular …, 2022 - frontiersin.org
The biomedical community is rapidly developing COVID-19 drugs to bring much-need
therapies to market, with over 900 drugs and drug combinations currently in clinical trials …

[HTML][HTML] COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

S Kumar, M Basu, P Ghosh, U Pal, MK Ghosh - Genes & Diseases, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated
disease COVID-19. Clinicians are continuously facing huge problems in the treatment of …

An overview on the current available treatment for COVID-19 and the impact of antibiotic administration during the pandemic

HSC Paula, SB Santiago, LA Araújo… - Brazilian Journal of …, 2021 - SciELO Brasil
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused
several problems in healthcare systems around the world, as to date, there is no effective …