[HTML][HTML] Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

[HTML][HTML] Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

[HTML][HTML] Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and …

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Sleep deprivation and neurological disorders

M Bishir, A Bhat, MM Essa, O Ekpo… - BioMed research …, 2020 - Wiley Online Library
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …

Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life

ES Donkor - Stroke research and treatment, 2018 - Wiley Online Library
Stroke is ranked as the second leading cause of death worldwide with an annual mortality
rate of about 5.5 million. Not only does the burden of stroke lie in the high mortality but the …

[HTML][HTML] Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological …

S Paul, S Chakraborty, U Anand, S Dey… - Biomedicine & …, 2021 - Elsevier
Abstract Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional
Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative …

[HTML][HTML] Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

AG Spiteri, CL Wishart, R Pamphlett, G Locatelli… - Acta …, 2022 - Springer
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

[HTML][HTML] Mechanistic insights and perspectives involved in neuroprotective action of quercetin

AK Grewal, TG Singh, D Sharma, V Sharma… - Biomedicine & …, 2021 - Elsevier
Neurodegenerative diseases (NDDs) are the primary cause of disabilities in the elderly
people. Growing evidence indicates that oxidative stress, mitochondrial dysfunction …