Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Basic experimental stem cell research has opened up the possibility of many diverse clinical
applications; however, translation to clinical trials has been restricted to only a few diseases …

The transplantation of glucose-responsive, insulin-producing cells offers the potential for
restoring glycemic control in individuals with diabetes. Pancreas transplantation and the …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Insulin-secreting pancreatic β-cells are essential regulators of mammalian metabolism. The
absence of functional β-cells leads to hyperglycemia and diabetes, making patients …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that leads to the loss of insulin-
producing beta cells. Bioartificial pancreas (BAP) or beta cell replacement strategies have …

Aims/hypothesis Islet transplantation is a promising cell therapy for patients with diabetes,
but it is currently limited by the reliance upon cadaveric donor tissue. We previously …

Advances in stem cell biology have afforded promising results for the generation of various
cell types for therapies against devastating diseases. However, a prerequisite for realizing …

The current epidemic of diabetes with its overwhelming burden on our healthcare system
requires better therapeutic strategies. Here we present a promising novel approach for a …

Islet transplantation for type 1 diabetes treatment has been limited by the need for lifelong
immunosuppression regimens. This challenge has prompted the development of …