Therapeutic potential of mesenchymal stem cells for cancer therapy

A Hmadcha, A Martin-Montalvo, BR Gauthier… - … in bioengineering and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for
regenerative medicine. A large number of studies have shown the beneficial effects of MSC …

Mesenchymal stem cell expressing TRAIL as targeted therapy against sensitised tumour

K Shaik Fakiruddin, N Ghazalli, MN Lim… - International journal of …, 2018 - mdpi.com
Tapping into the ability of engineered mesenchymal stem cells (MSCs) to mobilise into the
tumour has expanded the scope of cancer treatment. Engineered MSCs expressing tumour …

Enhanced anticancer efficacy of primed natural killer cells via coacervate-mediated exogenous interleukin-15 delivery

S Jeong, YG Kim, S Kim, K Kim - Biomaterials Science, 2022 - pubs.rsc.org
Effective exogenous delivery of interleukin (IL)-15 to natural killer (NK) cells with subsequent
anticancer efficacy could be a promising immune cell-based cancer immunotherapy. For the …

Mesenchymal stem cells engineered to secrete pigment epithelium-derived factor inhibit tumor metastasis and the formation of malignant ascites in a murine colorectal …

L Yang, Y Zhang, L Cheng, D Yue, J Ma… - Human gene …, 2016 - liebertpub.com
The therapeutic effects of conventional treatments for advanced colorectal cancer with
colorectal peritoneal carcinomatosis (CRPC) and malignant ascites are not very …

Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation

T Liu, Y Zhang, Z Shen, X Zou… - International …, 2017 - spandidos-publications.com
Recent studies have suggested that adipose tissue-derived mesenchymal stem cell (ADSC)
therapy and OX40 costimulation blockade are two immunomodulatory strategies used to …

Interplay between mesenchymal stem cell and tumor and potential application

Q Wang, T Li, W Wu, G Ding - Human Cell, 2020 - Springer
Mesenchymal stem cells (MSCs) possess the capabilities of self-renewal and multipotent
differentiation. Firstly isolated from bone marrow, MSCs are subsequently identified from …

[HTML][HTML] Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies

JN Li, W Li, LQ Cao, N Liu, K Zhang - World Journal of …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs), which are a kind of stem cell, possess an immune
privileged nature, tumour homing features, and multi-lineage differentiation ability. MSCs …

Comparison and immunobiological characterization of retinoic acid inducible gene-I-like receptor expression in mesenchymal stromal cells

G Raicevic, M Najar, H Busser, E Crompot, D Bron… - Scientific reports, 2017 - nature.com
Due to their immunomodulatory and regenerative properties, Mesenchymal stromal cells
(MSC) have generated major interests in several clinical settings including transplantation …

Combined treatment, based on lysomustine administration with mesenchymal stem cells expressing cytosine deaminase therapy, leads to pronounced murine Lewis …

LS Krassikova, SS Karshieva… - The journal of gene …, 2016 - Wiley Online Library
Background The combination of stem cell‐based gene therapy with chemotherapy
comprises an advantageous strategy that results in a reduction of system toxicity effects and …

间充质干细胞在癌症治疗中的应用潜能

瞿海龙, 梁璐, 边剑飞, 张冰 - 医学研究与教育, 2015 - yxyjyjy.hbu.edu.cn
干细胞在恶性肿瘤中的应用受到越来越多的研究与探讨. 间充质干细胞具有天然免疫豁免特性,
向肿瘤细胞迁移的能力, 多系分化的潜能, 使其成为抗肿瘤的一种生物制剂 …