Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Objective: The objective of the study was to evaluate the current state of clinical assays for
estradiol in the context of their applications. Participants: The participants were appointed by …

Although species can arise through hybridization, compelling evidence for hybrid speciation
has been reported only rarely in animals. Here, we present phylogenomic analyses on …

Abstract Context Most girls with Turner syndrome (TS) have hypergonadotropic
hypogonadism and need hormonal replacement for induction of puberty and then for …

Major advances in the characterization of uridine diphosphate (UDP)-
glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the …

Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily are responsible for the
metabolism of many drugs, environmental chemicals and endogenous compounds …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes
that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human …

The human uridine diphospho (UDP)-glucuronosyltransferase (UGT) superfamily comprises
enzymes responsible for a major biotransformation phase II pathway: the glucuronidation …