Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …

Breast cancer bone metastases (BCBM) result in serious skeletal morbidity. Although there
have been important advances in cancer treatment methods such as surgery and …

Bone cancer pain (BCP) is a pervasive clinical symptom which impairs the quality life. Long
noncoding RNAs (lncRNAs) are enriched in the central nervous system and play …

In the majority of patients with breast cancer in the advanced stages, skeletal metastases are
common, which may cause excruciating pain. Currently available drug treatments for relief of …

Globally, the prevalence of chronic pain is high at 10% to 50% of the adult population. 18,
23, 40, 57, 63, 64 Chronic pain not only impairs the quality of life of patients and their …

Simple Summary Bone metastases are one of the most common complications in patients
with advanced cancer that result in pain, which is usually severe, thereby significantly …

Simple Summary The mechanisms that underlie pain resulting from metastatic bone disease
remain elusive. This translates to a clinical and socioeconomic burden—targeted therapy is …

Metastatic bone pain is characterized by insufferable bone pain and abnormal bone
structure. A major goal of bone cancer treatment is to ameliorate osteolytic lesion induced by …

Cisplatin, which is a chemotherapy drug listed on the World Health Organisation's List of
Essential Medicines, commonly induces dose-limiting side effects including chemotherapy …

Purpose (i) To analyze age-adjusted incidence rates of synchronous bone metastases
diagnosed alongside primary malignancy from 2010 to 2018 in the US population,(ii) …