Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation …

RNA aptamers and RNA aptamer-based devices can be genetically encoded and
expressed in cells to probe and manipulate cellular function. However, their usefulness in …

Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

Background: Several types of RNA enzymes (ribozymes) have been identified in biological
systems and generated in the laboratory. Considering the variety of known RNA enzymes …

Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence‐
specific manner, and may be used for functional genomics, target validation and therapeutic …

Biologically active compounds which are light‐responsive offer experimental possibilities
which are otherwise very difficult to achieve. Since light can be manipulated very precisely …

Publisher Summary This chapter discusses how transcription templates are prepared by
cleaving the plasmid DNA with a restriction enzyme of choice. The individual nucleoside …

A detailed understanding of the susceptibility of RNA phosphodiesters to specific base-
catalyzed cleavage is necessary to approximate the stability of RNA under various …

RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of
RNA 3D structure prediction. With agreement from crystallographers, the RNA structures are …