Chromosome Duplication in Saccharomyces cerevisiae
SP Bell, K Labib - Genetics, 2016 - academic.oup.com
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
Signaling pathways of replication stress in yeast
Eukaryotic cells activate the S-phase checkpoint in response to a variety of events affecting
the progression of replication forks, collectively referred to as replication stress. This …
the progression of replication forks, collectively referred to as replication stress. This …
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …
[HTML][HTML] The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication
T Kubota, K Nishimura, MT Kanemaki, AD Donaldson - Molecular cell, 2013 - cell.com
The ring-shaped complex PCNA coordinates DNA replication, encircling DNA to act as a
polymerase clamp and a sliding platform to recruit other replication proteins. PCNA is …
polymerase clamp and a sliding platform to recruit other replication proteins. PCNA is …
Eukaryotic replisome components cooperate to process histones during chromosome replication
M Foltman, C Evrin, G De Piccoli, RC Jones… - Cell reports, 2013 - cell.com
DNA unwinding at eukaryotic replication forks displaces parental histones, which must be
redeposited onto nascent DNA in order to preserve chromatin structure. By screening …
redeposited onto nascent DNA in order to preserve chromatin structure. By screening …
PCNA loaders and unloaders—One ring that rules them all
During each cell duplication, the entirety of the genomic DNA in every cell must be
accurately and quickly copied. Given the short time available for the chore, the requirement …
accurately and quickly copied. Given the short time available for the chore, the requirement …
Replication-coupled PCNA unloading by the Elg1 complex occurs genome-wide and requires Okazaki fragment ligation
The sliding clamp PCNA is a crucial component of the DNA replication machinery. Timely
PCNA loading and unloading are central for genome integrity and must be strictly …
PCNA loading and unloading are central for genome integrity and must be strictly …
ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
Temporal and spatial regulation of the replication factory is important for efficient DNA
replication. However, the underlying molecular mechanisms are not well understood. Here …
replication. However, the underlying molecular mechanisms are not well understood. Here …
Polε instability drives replication stress, abnormal development, and tumorigenesis
R Bellelli, V Borel, C Logan, J Svendsen, DE Cox… - Molecular cell, 2018 - cell.com
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand
polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε …
polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε …
Chromatin enrichment for proteomics
G Kustatscher, KLH Wills, C Furlan, J Rappsilber - Nature protocols, 2014 - nature.com
During interphase, chromatin hosts fundamental cellular processes, such as gene
expression, DNA replication and DNA damage repair. To analyze chromatin on a proteomic …
expression, DNA replication and DNA damage repair. To analyze chromatin on a proteomic …