When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

At sites of vascular injury, platelets come into contact with subendothelial collagen, which
triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib …

Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

At sites of vascular injury, platelets come into contact with the subendothelial extracellular
matrix which triggers their activation and the formation of a hemostatic plug. This process is …

Platelets are specialized blood cells that play central roles in physiologic and pathologic
processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense …

Platelet adhesion on and activation by components of the extracellular matrix are crucial to
arrest post‐traumatic bleeding, but can also harm tissue by occluding diseased vessels …

Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the …

Molecular level studies on platelets deficient in collagen-induced aggregation provide
evidence for identifying possible platelet collagen receptors. We investigated platelets from …

WHEN IT WAS first identified, platelet glycoprotein GPIV was shown to have a remarkable
resistance to protease digestion. 1., 2. It was subsequently shown to be relatively increased …

Collagens are important platelet activators in the vascular subendothelium and vessel wall.
Since the regulation of platelet activation is a key step in distinguishing normal haemostasis …