Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

Recent years have witnessed a sea change in our understanding of transcription regulation:
whereas traditional models focused solely on the events that brought RNA polymerase II …

Pre-exposure to stress may alter plants' subsequent responses by producing faster and/or
stronger reactions implying that plants exercise a form of'stress memory'. The mechanisms of …

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …

Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of
transcription. In this study, we identified a 70-kDa Cyclin K (CycK) that binds Cdk12 and …

Plants are sessile organisms whose survival depends on their strategy to cope with
dynamic, stressful conditions. It is urgent to improve the ability of crops to adapt to recurrent …

Recognition of modified histones by 'reader'proteins plays a critical role in the regulation of
chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the …

Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …

Proper regulation of gene expression is essential for the differentiation, development and
survival of all cells and organisms. Recent work demonstrates that transcription of many …

Transcriptional regulation of developmentally controlled genes is at the heart of
differentiation and organogenesis. In this study, we performed global genomic analyses in …