Protein phosphorylation plays a cardinal role in regulating many cellular processes in
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …

Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

ROCK (Rho-kinase), an effector molecule of RhoA, phosphorylates the myosin binding
subunit (MBS) of myosin phosphatase and inhibits the phosphatase activity. This inhibition …

THOUSANDS OF PROTEINS are expressed in a typical mammalian cell, of which a third are
now thought to contain covalently bound phosphate. About 200 protein kinases and I00 …

The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes
potentially important for its growth-suppressing function. We have developed and used an …

The Ki-67 protein is a nuclear and nucleolar protein, which is tightly associated with somatic
cell proliferation. Antibodies raised against the human Ki-67 protein paved the way for the …

In the last 5 years, many features of the control of the cell cycle have been clarified. The
mitotic cycle is now understood as a biochemical pathway that generates from within the cell …

INTRODUCTION Phosphorylation of structural and regulatory proteins is a major
intracellular control mechanism in eukaryotes. The phosphoryl-ation state of a protein is a …

Methylation of lysine 4 on histone H3 (H3K4) at promoters is tightly linked to transcriptional
regulation in human cells. At least six different COMPASS-like multisubunit (SET1/MLL) …

Protein phosphatase 1 (PP1) is a serine/threonine protein phosphatase that is essential in
regulating diverse cellular processes. Here we report the crystal structure of the catalytic …