Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Type I interferons (IFNs) play essential roles in establishing and modulating host defense
against microbial infection via induction of IFN-stimulated genes (ISGs) through Janus …

Systemic lupus erythematosus (SLE) is characterized by multisystem immune-mediated
injury in the setting of autoimmunity to nuclear antigens. The clinical heterogeneity of SLE …

Outbreaks of severe virus infections with the potential to cause global pandemics are
increasing. In many instances these outbreaks have been newly emerging (SARS …

Objective The role of interferon‐α (IFNα) in the pathogenesis of systemic lupus
erythematosus (SLE) is strongly supported by gene expression studies. The aim of this study …

Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I
interferon (IFN-α/β) in response to foreign nucleic acids. Combined with their antigen …

Intestinal dysbiosis, characterized by a reduced Firmicutes/Bacteroidetes ratio, has been
reported in systemic lupus erythematosus (SLE) patients. In this study, in vitro cultures …

The concept of grouping Mendelian disorders associated with an upregulation of type I
interferon is not currently recognized in the medical literature. Here, we argue that such a …