Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend
off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological …

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …

Glioblastomas represent the most aggressive glioma grade and are associated with a poor
patient prognosis. The current standard of care, consisting of surgery, radiation and …

Apoptosis is a tightly regulated cellular process and faulty regulation of apoptosis is a
hallmark of human cancers. Targeting key apoptosis regulators with the goal to restore …

Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …

Evasion of cell death is one of the hallmarks of cancer cells, beginning with long‐
established apoptosis and extending to other new forms of cell death. An elaboration of cell …

Kinases and proteases are responsible for two fundamental regulatory mechanisms—
phosphorylation and proteolysis—that orchestrate the rhythms of life and death in all …

Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces
adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo …

Glioblastoma multiformes (GBMs) are extensively heterogeneous at both cellular and
molecular levels. Current therapeutic strategies include targeting of key signaling molecules …

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is
due to increased invasion, migration, proliferation, angiogenesis, and a decreased …