Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …

Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Scope It has been reported that eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) have anticonvulsant effects, yet the respective mechanism of EPA and DHA on …

Ferroptosis is an iron-dependent cell death mechanism involving the accumulation of lipid
peroxides. As a critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated …

Temporal lobe epilepsy (TLE) is associated with widespread brain alterations. Using
quantitative susceptibility mapping (QSM) alongside transverse relaxation rate (R 2*), we …

Neuroinflammation contributes to the generation of epilepsy and has been proposed as an
effective therapeutic target. Recent studies have uncovered the potential effects of the anti …

Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …

The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

Alterations in autophagy have been observed in epilepsy, although their exact
etiopathogenesis remains elusive. Transient Receptor Potential Mucolipin Protein 1 …