Vitamins C and E: beneficial effects from a mechanistic perspective
MG Traber, JF Stevens - Free radical biology and medicine, 2011 - Elsevier
The mechanistic properties of two dietary antioxidants that are required by humans, vitamins
C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an …
C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an …
The AlkB family of Fe (II)/α-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond
The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another …
messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another …
FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA
N 6-methyladenosine is a prevalent internal modification in messenger RNA and non-
coding RNA affecting various cellular pathways. Here we report the discovery of two …
coding RNA affecting various cellular pathways. Here we report the discovery of two …
Vitamin C in stem cell reprogramming and cancer
Vitamin C is an essential dietary requirement for humans. In addition to its known role as an
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …
Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
B Chen, F Ye, L Yu, G Jia, X Huang… - Journal of the …, 2012 - ACS Publications
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N 6-
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …
Mechanistic insights into substrate positioning that distinguish non-heme Fe (II)/α-ketoglutarate-dependent halogenases and hydroxylases
Non-heme iron halogenases and hydroxylases activate inert C–H bonds to selectively
catalyze the functionalization of diverse biological products under physiological conditions …
catalyze the functionalization of diverse biological products under physiological conditions …
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
Abstract ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid
oxygenase (NAOX) that catalyzes the demethylation of N 6-methyladenine in RNA. ALKBH5 …
oxygenase (NAOX) that catalyzes the demethylation of N 6-methyladenine in RNA. ALKBH5 …
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA
Abstract N 6-methyladenine (N 6-mA) of DNA is an emerging epigenetic mark in mammalian
genome. Levels of N 6-mA undergo drastic fluctuation during early embryogenesis …
genome. Levels of N 6-mA undergo drastic fluctuation during early embryogenesis …
Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases
WS Aik, MA McDonough, A Thalhammer… - Current opinion in …, 2012 - Elsevier
2-Oxoglutarate (2OG) and ferrous iron dependent oxygenases catalyze two-electron
oxidations of a range of small and large molecule substrates, including proteins/peptides …
oxidations of a range of small and large molecule substrates, including proteins/peptides …