Insulin action in the brain: cell types, circuits, and diseases

W Chen, W Cai, B Hoover, CR Kahn - Trends in neurosciences, 2022 - cell.com
Since its discovery over 100 years ago, insulin has been recognized as a key hormone in
control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and …

Anthocyanins in chronic diseases: The power of purple

SK Panchal, OD John, ML Mathai, L Brown - Nutrients, 2022 - mdpi.com
Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as
secondary metabolites are important in plant survival. Understanding their health benefits in …

Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

J Zhang, J Wu, F Liu, L Tong, Z Chen, J Chen… - European journal of …, 2019 - Elsevier
Anthocyanins, a class of water soluble flavonoids extracted from plants like berries and
soybean seed, have been shown to display obvious anti-oxidative, anti-inflammatory, and …

Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease

V Barrios, JA Chowen, Á Martín-Rivada… - Cells, 2021 - mdpi.com
The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles
during development, maturation, and aging. Members of this axis, composed of various …

Brain foods-the role of diet in brain performance and health

B Ekstrand, N Scheers, MK Rasmussen… - Nutrition …, 2021 - academic.oup.com
The performance of the human brain is based on an interplay between the inherited
genotype and external environmental factors, including diet. Food and nutrition, essential in …

Therapies in preclinical and clinical development for Angelman syndrome

T Markati, J Duis, L Servais - Expert Opinion on Investigational …, 2021 - Taylor & Francis
Introduction: Angelman syndrome is a rare genetic neurodevelopmental disorder, caused by
deficiency or abnormal function of the maternal ubiquitin protein-ligase E3A, known as …

Supplementation of blackcurrant anthocyanins increased cyclic glycine-proline in the cerebrospinal fluid of Parkinson patients: Potential treatment to improve insulin …

D Fan, Y Alamri, K Liu, M MacAskill, P Harris… - Nutrients, 2018 - mdpi.com
Background: Insulin-like growth factor-1 (IGF-1) function is impaired in Parkinson disease.
Cyclic glycine-proline (cGP), a metabolite of IGF-1, is neuroprotective through improving IGF …

The putative etiology and prevention of autism

G Steinman - Progress in molecular biology and translational …, 2020 - Elsevier
Since the initial psychological report by Leo Kanner in 1943, relatively little formal
biochemical/neurological research on the cause of autism, other than peripheral searches …

Growth factor concentrations in human milk are associated with infant weight and BMI from birth to 5 years

L Galante, S Pundir, H Lagström, S Rautava… - Frontiers in …, 2020 - frontiersin.org
Background: Human milk bioactives may play a role in infant health and development.
Although the variability in their concentrations in milk is well-established, the impact of …

Proline‐containing peptides—New insight and implications: A Review

M Misiura, W Miltyk - Biofactors, 2019 - Wiley Online Library
The family of regulatory proline‐containing peptides (PCPs), also known as glyprolines,
exhibit significant biological activity. The group of glyprolines includes Gly‐Pro (GP), Pro‐Gly …