Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA
synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by …

The cell cycle is a complex process that involves numerous regulatory proteins that direct
the cell through a specific sequence of events culminating in mitosis and the production of …

The association of cdk4 with D-type cyclins to form functional kinase complexes is
comparatively inefficient. This has led to the suggestion that assembly might be a regulated …

In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health …

Cyclin D1 is a multifunctional protein that activates CDK4 and CDK6, titrates Cip/Kip CDK
inhibitors to increase CDK2 activity, and modulates the function of certain transcription …

In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome,
which results in the accumulation of p21 and p27, leading to G1 arrest. Lovastatin is an …

Summary p27 Kip1 controls cell proliferation by binding to and regulating the activity of
cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and p27 stability are …

Abstract The nuclear hormone 1α, 25-dihydroxyvitamin D3 induces cell cycle arrest,
differentiation, or apoptosis depending on target cell type and state. Although the …