Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

The addiction‐relevant molecular, cellular, and behavioral actions of nicotine are derived
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …

Progress has been made over the last decade in our understanding of the brain areas and
circuits involved in nicotine reward and withdrawal, leading to models of addiction that …

A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors,
transporters, and synthesizing and degrading enzymes and regulators of their expression as …

Cigarette smoking is currently the leading cause of preventable deaths and disability
throughout the world, being responsible for about five million premature deaths/year …

The medial habenula (MHb) is considered a brain center regulating aversive states. The mu
opioid receptor (MOR) has been traditionally studied at the level of nociceptive and …

Cholinergic neurons in the medial habenula (MHb) modulate anxiety during nicotine
withdrawal although the molecular neuroadaptation (s) within the MHb that induce affective …