This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

MicroRNAs regulate gene expression through deadenylation, repression, and messenger
RNA (mRNA) decay. However, the contribution of each mechanism in non-steady-state …

INTRODUCTION Voltage-gated sodium (Nav) channels open and close ion-selective pores
in response to changes in membrane potential, and this gating underlies the generation of …

The transport of fluid in and around nanometer-sized objects with at least one characteristic
dimension below 100 nm enables the occurrence of phenomena that are impossible at …

The mechanism of ion channel voltage gating—how channels open and close in response
to voltage changes—has been debated since Hodgkin and Huxley's seminal discovery that …

The cell, as the most fundamental unit of life, is a microcosm of biology in which the
confluence of nearly all aspects of classical physics (mechanics, statistical physics …

Abstract Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and
muscle. This type of channel is gated directly by membrane voltage through protein domains …

In contrast to ordinary polymers, the vast majority of biological macromolecules adopt highly
ordered three-dimensional structures that define their functions. The key to folding of a …