Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC)
with a poor prognosis. Current treatment options are limited to surgery, adjuvant …

Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

The characterization of ligand binding modes is a crucial step in the drug discovery process
and is especially important in campaigns arising from phenotypic screening, where the …

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host
response to injury. It is activated rapidly within cells by many cytokines, most notably those in …

Hepatic fibrosis is a wound healing response that results in excessive extracellular matrix
(ECM) accumulation in response to chronic hepatic injury. Signal transducer and activator of …

Background & Aims The prevalence of non-alcoholic fatty liver disease (NAFLD) and its
severe form, non-alcoholic steatohepatitis (NASH), is increasing. Individuals with NASH …