In recent years, RNA-sequencing (RNA-seq) has emerged as a powerful technology for
transcriptome profiling. For a given gene, the number of mapped reads is not only …

Dozens of normalization methods for correcting experimental variation and bias in high-
throughput expression data have been developed during the last two decades. Up to 23 …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …

Co-expression networks have proven effective at assigning putative functions to genes
based on the functional annotation of their co-expressed partners, in candidate gene …

Between-sample normalization is a critical step in genomic data analysis to remove
systematic bias and unwanted technical variation in high-throughput data. Global …

Simple Summary Milk represents the main source of nutrition for newborn mammals and
serves as the conveyor of maternal messages of a sophisticated signaling system to …

Abstract Background Dormant Mycobacterium tuberculosis bacilli are believed to play an
important role in latent tuberculosis infection. Previously, we have demonstrated that …

The early detection of cancer holds the key to combat and control the increasing global
burden of cancer morbidity and mortality. Blood-based screenings using circulating DNAs …

To use next-generation sequencing technology such as RNA-seq for medical and health
applications, choosing proper analysis methods for biomarker identification remains a …