Synaptic connectivity defines groups of neurons that engage in correlated activity during
specific functional tasks. These co-active groups of neurons form ensembles, the operational …

The cerebellum governs motor coordination and motor learning. Infection with external
microorganisms, such as viruses, bacteria, and fungi, induces the release and production of …

Cerebellar dysfunction relates to various psychiatric disorders, including autism spectrum
and depressive disorders. However, the physiological aspect is less advanced. Here, we …

Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such …

Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory
formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation …

Cerebellar-based learning is thought to rely on synaptic plasticity, particularly at synaptic
inputs to Purkinje cells. Recently, however, other complementary mechanisms have been …

The cerebellum, the site where protein kinase C (PKC) was first discovered, contains the
highest amount of PKC in the central nervous system, with PKCγ being the major isoform …

A hexanucleotide (GGGGCC) repeat expansion in the first intron of the C9ORF72 gene is
the most frequently reported genetic cause of amyotrophic lateral sclerosis (ALS) and …

Persistent changes that occur in brain circuits are classically thought to be mediated by long-
term modifications in synaptic efficacy. Yet, many studies have shown that voltage-gated ion …

Key points Spike doublets comprise∼ 10% of in vivo complex spike events under
spontaneous conditions and∼ 20%(up to 50%) under evoked conditions. Under near …