Beyond histone acetylation—writing and erasing histone acylations
Highlights•Non-acetyl histone acylations are catalyzed by classical acetylation
modifiers.•Active site engagement of the acyl group determines acyl type-specific …
modifiers.•Active site engagement of the acyl group determines acyl type-specific …
Now open: evolving insights to the roles of lysine acetylation in chromatin organization and function
Protein acetylation is conserved across phylogeny and has been recognized as one of the
most prominent post-translational modifications since its discovery nearly 60 years ago …
most prominent post-translational modifications since its discovery nearly 60 years ago …
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
B Yue, C Song, L Yang, R Cui, X Cheng, Z Zhang… - Molecular cancer, 2019 - Springer
Background As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
Background Representing biological networks as graphs is a powerful approach to reveal
underlying patterns, signatures, and critical components from high-throughput biomolecular …
underlying patterns, signatures, and critical components from high-throughput biomolecular …
TAZ/YAP fusion proteins: Mechanistic insights and therapeutic opportunities
The Hippo pathway is dysregulated in many different cancers, but point mutations in the
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …
ZZ-dependent regulation of p62/SQSTM1 in autophagy
Autophagic receptor p62 is a critical mediator of cell detoxification, stress response, and
metabolic programs and is commonly deregulated in human diseases. The diverse functions …
metabolic programs and is commonly deregulated in human diseases. The diverse functions …
TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition
The histone acetyltransferase p300/CBP is composed of several conserved domains,
among which, the TAZ2 domain is known as a protein-protein interaction domain that binds …
among which, the TAZ2 domain is known as a protein-protein interaction domain that binds …
Dynamic modules of the coactivator SAGA in eukaryotic transcription
Abstract SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex
N Merritt, K Garcia, D Rajendran, ZY Lin, X Zhang… - Elife, 2021 - elifesciences.org
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in
its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 …
its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 …
YEATS domains as novel epigenetic readers: structures, functions, and inhibitor development
Interpretation of the histone posttranslational modifications (PTMs) by effector proteins, or
readers, is an important epigenetic mechanism to regulate gene function. YEATS domains …
readers, is an important epigenetic mechanism to regulate gene function. YEATS domains …