Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
Blood-to-brain communication in aging and rejuvenation
Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …
Exercise hormone irisin is a critical regulator of cognitive function
Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …
The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
[HTML][HTML] Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
D da Luz Scheffer, A Latini - … et Biophysica Acta (BBA)-Molecular Basis of …, 2020 - Elsevier
A wide array of molecular pathways has been investigated during the past decade in order
to understand the mechanisms by which the practice of physical exercise promotes …
to understand the mechanisms by which the practice of physical exercise promotes …
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
AM Horowitz, X Fan, G Bieri, LK Smith… - Science, 2020 - science.org
Reversing brain aging may be possible through systemic interventions such as exercise. We
found that administration of circulating blood factors in plasma from exercised aged mice …
found that administration of circulating blood factors in plasma from exercised aged mice …
Effects of physical exercise on cognitive functioning and wellbeing: biological and psychological benefits
L Mandolesi, A Polverino, S Montuori, F Foti… - Frontiers in …, 2018 - frontiersin.org
Much evidence shows that physical exercise (PE) is a strong gene modulator that induces
structural and functional changes in the brain, determining enormous benefit on both …
structural and functional changes in the brain, determining enormous benefit on both …