BCG immunotherapy is the gold-standard treatment for non-muscle-invasive bladder cancer
at high risk of recurrence or progression. Preclinical and clinical studies have revealed that a …

Microbial surface components recognizing adhesive matrix molecules (MSCRAMMs)
comprise a group of cell surface adhesins that bind specifically to the extracellular matrix …

Mycobacterium tuberculosis is known to synthesize α-, methoxy-, and keto-mycolic acids.
We propose a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis …

Intracellular bacteria are endowed with the capacity to survive and replicate inside
mononuclear phagocytes (MP) and, sometimes, within certain other host cells. MP are …

The large number of different proteins synthesized by the mycobacterial cell are currently
classified and studied in terms of groups of proteins with certain common properties such as …

Mycobacterium avium complex (MAC) disease emerged early in the epidemic of AIDS as
one of the common opportunistic infections afflicting human immunodeficiency virus-infected …

In 1993, the WHO declared tuberculosis a global emergency on the basis that there are 8
million new cases per year. The complete genome of the strain H37Rv of the causative …

Proteins secreted from Mycobacterium tuberculosis during growth are believed to be
important for protective immunity against tuberculosis. We have investigated the growth of M …

Five actively secreted proteins (MPT32, MPT45, MPT51, MPT53, and MPT63) and the
MPT46 protein were purified to homogeneity from Mycobacterium tuberculosis culture fluid …

The T cell-mediated acquired immune response to infection with Mycobacterium
tuberculosis, both in humans and in experimental models in the mouse, is a complex event …