Autosomal dominant polycystic kidney disease is characterized by progressive development
and enlargement of kidney cysts, leading to ESKD. Because the kidneys are under high …

Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD)
progression in mouse models, but whether the effect was due to solely reduced calories or …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the leading causes of end-
stage renal disease. In spite of the recent tremendous progress in the understanding of …

Background Our laboratory published the first evidence that nutritional ketosis, induced by a
ketogenic diet (KD) or time-restricted diet (TRD), ameliorates disease progression in …

Introduction Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited kidney disease that leads to eventual renal failure. Metformin (MET), an AMP …

Abstract mTOR activation is essential and sufficient to cause polycystic kidneys in Tuberous
Sclerosis Complex (TSC) and other genetic disorders. In disease models, a sharp increase …

Abstract Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the
most common causes of end-stage renal failure, caused by mutations in PKD1 or PKD2 …

Autosomal polycystic kidney disease is the most common inherited kidney disease
determining 5% of all end-stage kidney disease. The only therapy approved for this …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common
inherited renal disorder, characterized by renal cyst development leading to end-stage renal …

The most common form of polycystic kidney disease (PKD) in humans is caused by
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …