Abstract Purpose of Review Atherosclerosis is now considered a chronic inflammatory
disease. Oxidative stress induced by generation of excess reactive oxygen species has …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

Upon reaction with electrons, oxygen is transformed into reactive oxygen species (ROS). It
has long been known that ROS can destroy bacteria and destroy human cells, but research …

Significance: Mitochondrial and cellular reactive oxygen species (ROS) play important roles
in both physiological and pathological processes. Different ROS, such as superoxide (O2•−) …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Metabolism of oxygen by cells generates potentially deleterious reactive oxygen species
(ROS). Under normal conditions the rate and magnitude of oxidant formation is balanced by …

Background—A significant number of patients treated with anthracyclines develop
cardiotoxicity (anthracycline-induced cardiotoxicity [ACT]), mainly presenting as arrhythmias …

The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the
microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs) to eradicate …

Reactive oxygen species (ROS) are thought to have effects on T-cell function and
proliferation. Low concentrations of ROS in T cells are a prerequisite for cell survival, and …