Simple Summary Immunotherapy is a rapidly advancing field in breast cancer treatment,
however, it encounters many obstacles that leave open gateways for breast cancer cells to …

CD8+ T cell reactivity towards tumor mutation-derived neoantigens is widely believed to
facilitate the antitumor immunity induced by immune checkpoint blockade (ICB). Here we …

Estrogen signaling has been implicated in hormone-dependent breast cancer which
constitutes> 75% of breast cancer diagnosis and other malignancies. Aromatase, the key …

Methods This study examined the effects of exercise training for 8 weeks on blood immune
cell characteristics among 20 breast cancer survivors (age 56±6 years, Body Mass Index …

The UV-mediated peptide exchange has enabled the generation of multiple different MHC
multimer specificities in parallel, surpassing tedious individual refolding of MHC molecules …

Background aims Human telomerase reverse transcriptase (hTERT) is an attractive target for
anti-cancer therapies. We developed an effective method for generating hTERT-specific …

Simple Summary Vδ2+ γδ T cells have potent antitumor properties both in vitro and in
murine preclinical models of breast cancers. However, in the context of human breast …

Worldwide, gastrointestinal (GI) cancer is recognized as one of the leading malignancies
diagnosed in both genders, with mortality largely attributed to metastatic dissemination. It …

Highlights•T cell specificities can be determined through TCR sequencing based and
peptide-HLA complex based technologies.•A peptide-HLA complex can be generated for …

During the past decade, an abundance of scientific advancements have been made in the
field of immunology. With these advancements, greater understanding of immune regulation …