Owing to the increase in multidrug‐resistant bacterial isolates in hospitals globally and the
lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have …

Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …

Despite the wide use of antibiotics, bacterial infection is still one of the leading causes of
hospitalization and mortality. The clinical failure of antibiotic therapy is linked with low …

Due to rapid development of bacterial resistance against antibiotics, an emerging health
crisis is underway, where 'simple'infections may no longer be treatable. Antimicrobial …

Antimicrobial peptides (AMPs) are a class of promising anti-infective molecules but their
therapeutic application is opposed by their poor bioavailability, susceptibility to protease …

Here, we describe novel polyion complex (PIC) particles for the delivery of Polymyxin B (Pol-
B), an antimicrobial peptide currently used in the clinic as a last resort antibiotic against …

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging
health crisis, in which 'simple'infections may no longer be treatable. One class of molecules …

Antimicrobial peptides (AMPs) are antibiotics with the potential to address antimicrobial
resistance. However, their translation to the clinic is hampered by issues such as off‐target …

Here, we describe the preparation and characterisation of polyion complex (PIC)
nanoparticles containing last resort antimicrobial polymyxin B (Pol-B). PIC nanoparticles …

To combat the ever-growing increase of multidrug-resistant (MDR) bacteria, action must be
taken in the development of antibiotic formulations. Colistin, an effective antibiotic, was …