Knee osteoarthritis is the most common joint disease. It causes pain and suffering for
affected patients and is the source of major economic costs for healthcare systems. Despite …

ABSTRACT Bone morphogenetic protein 2 (BMP-2) has been known for decades as a
strong osteoinductive factor and for clinical applications is combined solely with collagen as …

The CRISPR/Cas9 mechanism offers promising therapeutic approaches for bone
regeneration by stimulating or suppressing critical signaling pathways. In this study, we …

In the cellular microenvironment, growth factor gradients are crucial in dictating cell fate.
Towards developing materials that capture the native microenvironment we engineered …

Growth factors, first known for their essential role in the initiation of mitosis, are required for a
variety of cellular processes and their localized delivery is considered as a rational …

During development, growth factors (GFs) such as bone morphogenetic proteins (BMPs)
exert important functions in several tissues by regulating signaling for cell differentiation and …

Within the native microenvironment, extracellular matrix (ECM) components are thought to
display a complex and heterogeneous distribution, spanning several length scales. Herein …

Healing of bone fractures describes a remarkable process in that the injured tissue heals
without scar formation, thus typically resulting in a complete regeneration of the bones …

Extracellular matrix remodeling plays a pivotal role during mesenchyme patterning into
different lineages. Tension exerted from cell membrane receptors bound to extracellular …

The native microenvironment of mesenchymal stem cells (hMSCs)—the extracellular matrix
(ECM), is a complex and heterogenous environment structured at different scales. The …