The DNA of eukaryotic cells is spooled around large histone protein complexes, forming
nucleosomes that make up the basis for a high-order packaging structure called chromatin …

Understanding how chromatin is spatially and dynamically organized in the nucleus of
eukaryotic cells and how this affects genome functions is one of the main challenges of cell …

Nucleosome positioning has important roles in key cellular processes. Although intensive
efforts have been made in this area, the rules defining nucleosome positioning is still elusive …

Nucleosomal DNA is thought to be generally inaccessible to DNA-binding factors, such as
micrococcal nuclease (MNase). Here, we digest Drosophila chromatin with high and low …

Nucleosome positioning dictates eukaryotic DNA compaction and access. To predict
nucleosome positions in a statistical mechanics model, we exploited the knowledge that …

Establishment of stable HIV-1 infection requires the efficient integration of the retroviral
genome into the host DNA. The molecular mechanism underlying the control of this process …

The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA
sequence are readily accessible for regulatory proteins and which are not. Genome-wide …

Statistical–mechanical lattice models for protein–DNA binding are well established as a
method to describe complex ligand binding equilibria measured in vitro with purified DNA …

Background Retroviral integration depends on the interaction between intasomes, host
chromatin and cellular targeting cofactors as LEDGF/p75 or BET proteins. Previous studies …

Contribution of histone sequence preferences to nucleosome organization: proposed
definitions and methodology | Genome Biology Skip to main content SpringerLink Account …