Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

(S)-Glutamic acid (Glu), which is the main excitatory neurotransmitter in the central nervous
system (CNS), and other excitatory amino acids (EAAs) operate through four different …

Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all
aspects of neuronal function. Disruption of normal glutamate transmission has been …

In the first part of this review1 we discussed the important role that α, α-disubstituted amino
acids have played in the design of peptides with enhanced properties, owing to the …

The main excitatory neurotransmitter in the brain, glutamate (Glu), activates not only receptor-
channels, but also receptors coupled to G-protein called metabotropic Glu receptors …

Appreciation of the pharmacology and function of ionotropic excitatory amino acid receptors
(NMDA, AMPA, kainate) was greatly extended during the 1980s due to the availability of …

Hydantoins and their hybrids with other molecules represent a very important group of
heterocycles because they exhibit diverse biological and pharmacological activities in …

Discovery of mGlu receptors has dramatically influenced our understanding of glutamatergic
neurotransmission in the central nervous system. This receptor family provides a mechanism …

The four stereoisomers of 1-aminocyclopentane-1, 3, 4-tricarboxylic acid {ACPT-I (18) and-II
(19),(3 R, 4 R)-III [(−)-20], and (3 S, 4 S)-III [(+)-20]} have been synthesized and evaluated for …

A high‐throughput screening of candidate nitrilases against 25 structurally diverse
substrates allowed us to create a wide collection of 125 experimentally validated nitrilases …