Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

B Lomonte - Toxicon, 2023 - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

The allosteric activation mechanism of a phospholipase A2-like toxin from Bothrops jararacussu venom: a dynamic description

AAS Gomes, FF Cardoso, MF Souza, CLP Oliveira… - Scientific Reports, 2020 - nature.com
The activation process of phospholipase A2-like (PLA2-like) toxins is a key step in their
molecular mechanism, which involves oligomeric changes leading to the exposure of …

Viper venom phospholipase A2 database: the structural and functional anatomy of a primary toxin in envenomation

ALN de Oliveira, MT Lacerda, MJ Ramos… - Toxins, 2024 - mdpi.com
Viper venom phospholipase A2 enzymes (vvPLA2s) and phospholipase A2-like (PLA2-like)
proteins are two of the principal toxins in viper venom that are responsible for the severe …

Understanding the mechanism of action of peptide (p-BthTX-I) 2 derived from C-terminal region of phospholipase A2 (PLA2)-like bothropstoxin-I on Gram-positive and …

NA Santos-Filho, LM de Freitas, CT Dos Santos… - Toxicon, 2021 - Elsevier
Based on the antimicrobial activity of bothropstoxin-I (BthTX-I) and on the premise that a C-
terminal peptide of Lys49 myotoxin can reproduce the antimicrobial activity of the parent …

SDS-induced hexameric oligomerization of myotoxin-II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance

A Henrickson, T Montina, P Hazendonk… - European Biophysics …, 2023 - Springer
We report the solution behavior, oligomerization state, and structural details of myotoxin-II
purified from the venom of Bothrops asper in the presence and absence of sodium dodecyl …

Focused Proteomics Analysis of Habu Snake (Protobothrops flavoviridis) Venom Using Antivenom-Based Affinity Chromatography Reveals Novel Myonecrosis …

T Ogawa, Y Tobishima, S Kamata, Y Matsuda… - Frontiers in …, 2021 - frontiersin.org
Snakebites are one of the major causes of death and long-term disability in the developing
countries due to the presence of various bioactive peptides and proteins in snake venom. In …

Supramolecular Hybrids of Proteins from Habu Snake Venom with Discrete [Pt(CN)4]2– Complex

K Kuroiwa, Y Matsumura, K Nagano… - … Applied Materials & …, 2024 - ACS Publications
The venom of the Habu snake Protobothrops flavoviridis (P. flavoviridis) is known to contain
a diverse array of proteins and peptides, with a notable presence of phospholipase A2 …

[HTML][HTML] In-solution structural studies involving a phospholipase A2-like myotoxin and a natural inhibitor: Plasticity of oligomeric assembly affects mechanisms of …

FF Cardoso, MF de Souza, CLP Oliveira, MRM Fontes - Biochimie, 2021 - Elsevier
Snakebite envenomation has been categorized by World Health Organization as a category
A neglected tropical disease, since it causes chronic psychological disorders, physical …

Venom Profiling of the Insular Species Bothrops alcatraz: Characterization of Proteome, Glycoproteome, and N-Terminome Using Terminal Amine Isotopic Labeling …

D Andrade-Silva, A Zelanis… - Journal of Proteome …, 2021 - ACS Publications
Bothrops alcatraz, a species endemic to Alcatrazes Islands, is regarded as critically
endangered due to its small area of occurrence and the declining quality of its habitat. We …