A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The recent outbreaks of avian influenza A (H5N1) virus, its expanding geographic
distribution and its ability to transfer to humans and cause severe infection have raised …

Reductive amination is an important tool for synthetic organic chemists in the construction of
carbon‐nitrogen bonds. This reaction, also termed reductive alkylation, involves …

Currently, smallpox, caused by the variola virus belonging to the poxvirus family, has been
completely eradicated according to the WHO. However, other representatives of poxviruses …

In 1900, Bayer created the first spiran described as a bicyclic hydrocarbon connected by a
single carbon. The term spirocyclanes was used to describe the family of such hydocarbon …

A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2,
and versatile substituents on the nitrogen atom of the thiazolidine ring, were synthesized …

Developing novel antimicrobial agents has become a necessitate due to the increasing rate
of microbial resistance to antibiotics. All the newly adamantane derivatives were evaluated …

Synthetic spiro [pyrrolidine-2, 2′-adamantanes] 2, 3, 11, 15, 12, 16, 18, 20 were evaluated
in vitro and found to be active anti-influenza virus A compounds; the effect of the position of …

We tested two approaches to overcoming resistance of influenza A viruses against
adamantane derivatives. First, adamantane derivatives that interfere with the ion channel …

Several adamantanes have established actions against coronaviruses. Amantadine,
rimantadine, bananins and the structurally related memantine are effective against human …