The association of tubulin with the plasma membrane comprises multiple levels of
penetration into the bilayer: from integral membrane protein, to attachment via …

BACKGROUND AND PURPOSE The two longest C‐termini of the purinergic P2X receptors
occur in the P2X2 and P2X7 receptors and are thought to interact with multiple cytoplasmic …

Ionotropic P2X and metabotropic P2Y receptors interact with a number of macromolecules in
the cell membrane which may contribute to their functional plasticity. P2X receptors are …

Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve
refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias …

In the present study, treatment of HEK-293 cells with the synthetic small molecule N-
iodoacetyl-tryptophan (I-Trp) at submicromolar concentrations efficiently induced cell …

The cellular effects of purines and pyrimidines are mediated through an extended
superfamily of purinoceptors, which include metabotropic P1 (adenosine) receptors, and P2 …

Existence of microtubule cytoskeleton at the membrane and submembranous regions,
referred as 'membrane tubulin'has remained controversial for a long time. Since we reported …

The cytoplasmic loop between the second and third transmembrane segments is pivotal in
the regulation of TRESK (TWIK-related spinal cord K+ channel, K2P18. 1, KCNK18) …

P2X2 plays an important role in ATP signaling in guinea pig myenteric plexus. Here, we
cloned and characterized three P2X2 isoforms expressed in myenteric neurons. RT/PCR …

Abstract P2X2 receptor (P2X2R) belongs to the family of purinergic receptors that have been
shown to play important roles in regulating host innate immune response. Although the …