The therapeutic value of synergistic interactions has been known since antiquity, and many
different cultural healing systems still rely on this principle in the belief that combination …

This Guidance document describes harmonised risk assessment methodologies for
combined exposure to multiple chemicals for all relevant areas within EFSA's remit, ie …

This study was to compare several published methodologies for evaluating the nature of
drug-drug combination, ie, curve-shift analysis, isobologram, combination index, and …

The concise yet authoritative presentation of key techniques for basic mixtures experiments
Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments …

Synergism and antagonism are often defined in relation to the model of Concentration
Addition (CA). Hence, it is vital for the conclusion of mixture toxicity studies to be able to test …

Binary mixture studies are well established for mixtures of pollutants, pesticides, or
allelochemicals and sound statistical methods are available to evaluate the results in …

In this paper we present and discuss a novel, simple and easy to implement parametric
modeling approach to assess synergy. An extended three parameter log‐logistic model is …

The toxicity of the antifouling compounds diuron, irgarol, zinc pyrithione (ZnPT), copper
pyrithione (CuPT) and copper was tested on the three marine microalgae Tisochrysis lutea …

When multiple drugs are administered simultaneously, investigators are often interested in
assessing whether the drug combinations are synergistic, additive, or antagonistic. Based …

A Hill-type time-response curve was derived using a single-step chemical kinetics
approximation. The rate expression for the transformation is a differential equation that …