Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications

L Dayon, O Cominetti, M Affolter - Expert review of proteomics, 2022 - Taylor & Francis
Introduction Biological fluids are routine samples for diagnostic testing and monitoring.
Blood samples are typically measured because of their moderate invasive collection and …

Tear and ocular surface disease biomarkers: A diagnostic and clinical perspective for ocular allergies and dry eye disease

T Suárez-Cortés, N Merino-Inda… - Experimental Eye …, 2022 - Elsevier
Validated biomarkers to be used as biological tools for managing ocular surface diseases
(OSDs) are still an unmet need in daily clinical practice. Many studies have contributed to …

Tear-based vibrational spectroscopy applied to amyotrophic lateral sclerosis

D Ami, A Duse, P Mereghetti, F Cozza… - Analytical …, 2021 - ACS Publications
Biofluid analysis by optical spectroscopy techniques is attracting considerable interest due
to its potential to revolutionize diagnostics and precision medicine, particularly for …

Viscoelastic properties of the human tear film

A Recchioni, E Mocciardini, E Ponzini… - Experimental Eye …, 2022 - Elsevier
When considering eye blinking from a tribological perspective, tear viscosity is expected to
play a fundamental role. The application of rheological techniques to describe the tear film …

Proteomic analysis of tears and conjunctival cells collected with Schirmer strips using timsTOF Pro: Preanalytical considerations

M Akkurt Arslan, I Kolman, C Pionneau, S Chardonnet… - Metabolites, 2021 - mdpi.com
This study aimed to investigate the human proteome profile of samples collected from whole
(W) Schirmer strips (ScS) and their two parts—the bulb (B) and the rest of the strip (R)—with …

Targeted Workflow Investigating Variations in the Tear Proteome by Liquid Chromatography Tandem Mass Spectrometry

M Lépine, O Zambito, L Sleno - ACS omega, 2023 - ACS Publications
Proteins in tears have an important role in eye health and have been shown as a promising
source of disease biomarkers. The goal of this study was to develop a robust, sensitive, and …

Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures

P Amini, JO Okeme - Current environmental health reports, 2024 - Springer
Purpose Exposures to hazardous chemicals have been linked to many detrimental health
effects and it is therefore critical to have effective biomonitoring methods to better evaluate …

A review of emerging tear proteomics research on the ocular surface in ocular allergy

E Aydin, P Dhar, M Gokhale, L Chong, S Azizoglu… - Biology, 2022 - mdpi.com
Simple Summary Ocular allergy is a localised form of allergy occurring on the surface of the
eye and surrounding tissues. Typical signs and symptoms of ocular allergy include itching …

Systems biology approach to investigate biomarkers, boron-10 carriers, and mechanisms useful for improving boron neutron capture therapy

D Perico, D Di Silvestre, S Imamichi… - Cancer Biotherapy & …, 2023 - liebertpub.com
Systems biology approach, carried out with high-throughput omics technologies, has
become a fundamental aspect of the study of complex diseases like cancer. It can …

Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface

M Akkurt Arslan, F Brignole-Baudouin, S Chardonnet… - Scientific Reports, 2023 - nature.com
The ocular surface (OS) enzymes are of great interest due to their potential for novel ocular
drug development. We aimed first to profile and classify the enzymes of the OS to describe …