Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …

Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex
interplay of several pathways, including inflammation, immune activation, hypoxia, and …

Sepsis is one of the main causes of death among critically ill patients. Sepsis pathogenesis
includes infection by gram-negative and gram-positive bacteria, fungi, or both; exacerbated …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. Myocardial dysfunction, often termed sepsis-induced cardiomyopathy …

Sepsis is a major cause of morbidity and mortality in critically ill patients, and despite
advances in management, mortality remains high. In survivors, sepsis increases the risk for …

Malaria causes an acute systemic human disease that bears many similarities, both
clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the …

Skeletal muscle is the most abundant tissue in the body and is required for numerous vital
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …

Rationale: Mitochondrial damage is an important component of multiple organ failure
syndrome, a highly lethal complication of severe sepsis that lacks specific therapy …

Sepsis and multiple organ dysfunction syndrome (MODS) are major causes of morbidity and
mortality in the intensive care unit. Recently mitochondrial dysfunction has been proposed …

Sepsis is a complex pathophysiological disorder arising from a systemic inflammatory
response to infection. Patients are clinically classified according to the presence of signs of …