Computational methods and biomarker discovery strategies for spatial proteomics: a review in immuno-oncology
Advancements in imaging technologies have revolutionized our ability to deeply profile
pathological tissue architectures, generating large volumes of imaging data with …
pathological tissue architectures, generating large volumes of imaging data with …
Physiologically based pharmacokinetic modeling of nanoparticle biodistribution: a review of existing models, simulation software, and data analysis tools
EO Kutumova, IR Akberdin, IN Kiselev… - International Journal of …, 2022 - mdpi.com
Cancer treatment and pharmaceutical development require targeted treatment and less toxic
therapeutic intervention to achieve real progress against this disease. In this scenario …
therapeutic intervention to achieve real progress against this disease. In this scenario …
Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy
ZZ Reinstein, Y Zhang, OE Ospina, MD Nichols… - Cancer …, 2024 - aacrjournals.org
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with a∼ 50%
response rate to immune checkpoint blockade (ICB) therapy. To identify predictive …
response rate to immune checkpoint blockade (ICB) therapy. To identify predictive …
SPF: a spatial and functional data analytic approach to cell imaging data
The tumor microenvironment (TME), which characterizes the tumor and its surroundings,
plays a critical role in understanding cancer development and progression. Recent …
plays a critical role in understanding cancer development and progression. Recent …
Tumor immune cell clustering and its association with survival in African American women with ovarian cancer
New technologies, such as multiplex immunofluorescence microscopy (mIF), are being
developed and used for the assessment and visualization of the tumor immune …
developed and used for the assessment and visualization of the tumor immune …
Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment
Immunotherapy has improved survival for patients with advanced clear cell renal cell
carcinoma (ccRCC), but resistance to therapy develops in most patients. We use cellular …
carcinoma (ccRCC), but resistance to therapy develops in most patients. We use cellular …
mxfda: a comprehensive toolkit for functional data analysis of single-cell spatial data
Technologies that produce spatial single-cell (SC) data have revolutionized the study of
tissue microstructures and promise to advance personalized treatment of cancer by …
tissue microstructures and promise to advance personalized treatment of cancer by …
Statistical analysis of multiplex immunofluorescence and immunohistochemistry imaging data
Advances in multiplexed single-cell immunofluorescence (mIF) and multiplex
immunohistochemistry (mIHC) imaging technologies have enabled the analysis of cell-to …
immunohistochemistry (mIHC) imaging technologies have enabled the analysis of cell-to …
Statistical analysis of multiple regions-of-interest in multiplexed spatial proteomics data
S Samorodnitsky, MC Wu - Briefings in Bioinformatics, 2024 - academic.oup.com
Multiplexed spatial proteomics reveals the spatial organization of cells in tumors, which is
associated with important clinical outcomes such as survival and treatment response. This …
associated with important clinical outcomes such as survival and treatment response. This …
Statistical Analysis of Quantitative Cancer Imaging Data
Recent advances in types and extant of medical imaging technologies has led to
proliferation of multimodal quantitative imaging data in cancer. Quantitative medical imaging …
proliferation of multimodal quantitative imaging data in cancer. Quantitative medical imaging …