The development of dialysis by early pioneers such as Willem Kolff and Belding Scribner set
in motion several dramatic changes in the epidemiology, economics and ethical frameworks …

Background End-stage kidney disease is a leading cause of morbidity and mortality
worldwide. Prevalence of the disease and worldwide use of renal replacement therapy …

Chronic kidney disease (CKD) is a common comorbidity in patients with type 2 diabetes
mellitus (T2DM) and both conditions are increasing in prevalence. CKD is estimated to …

Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below
15 mL/min per 1· 73 m 2—have an unacceptably high mortality rate. In developing countries …

TGF-β has been implicated as a major pathogenic factor in diabetic nephropathy. This
randomized, double-blind, phase 2 study assessed whether modulating TGF-β1 activity with …

Chronic kidney disease (CKD) is a major risk factor for endstage renal disease,
cardiovascular disease, and premature death. Here we estimated the global prevalence and …

Background The burden of end-stage kidney disease (ESKD) in sub-Saharan Africa is
unknown but is probably high. Access to dialysis for ESKD is limited by insufficient …

Cardiovascular, respiratory, and related disorders (CVRDs) are the leading causes of adult
death worldwide, and substantial inequalities in care of patients with CVRDs exist between …

Early detection is a key strategy to prevent kidney disease, its progression and related
complications, but numerous studies show that awareness of kidney disease at the …

Background There is increased interest in understanding why chronic kidney disease (CKD)
rates vary across races and socioeconomic groups. We investigated the distribution of …