Symmetry is a common feature among natural systems, including protein structures. A strong
propensity toward symmetric architectures has long been recognized for water-soluble …

The seemingly limitless diversity of proteins in nature arose from only a few thousand
domain prototypes, but the origin of these themselves has remained unclear. We are …

Highlights•About 20% of SCOP folds, superfamilies and families have internal symmetry.•All-
β and membrane folds and superfamilies are the most prominent in symmetry.•Connecting …

A correct assessment of the quaternary structure of proteins is a fundamental prerequisite to
understanding their function, physico-chemical properties and mode of interaction with other …

The lethal factor in stonefish venom is stonustoxin (SNTX), a heterodimeric cytolytic protein
that induces cardiovascular collapse in humans and native predators. Here, using X-ray …

Secondary active transporters are critical for neurotransmitter clearance and recycling
during synaptic transmission and uptake of nutrients. These proteins mediate the movement …

Many proteins fold into highly regular and repetitive three dimensional structures. The
analysis of structural patterns and repeated elements is fundamental to understand protein …

The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-
H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers …

Transport of ions and small molecules across the cell membrane against electrochemical
gradients is catalyzed by integral membrane proteins that use a source of free energy to …

Symmetry in protein, and, more generally, in macromolecular assemblies is a key point to
understand their structure, stability and function. Many symmetrical assemblies are currently …