In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …

Translation and decay of eukaryotic mRNAs is controlled by shortening of the poly (A) tail
and release of the poly (A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two …

Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription,
splicing, and polyadenylation. However, the relationship between human transcript diversity …

In animal oocytes and early embryos, mRNA poly (A)-tail length strongly influences
translational efficiency (TE), but later in development this coupling between tail length and …

In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …

Summary mRNAs form ribonucleoprotein complexes (mRNPs) by association with proteins
that are crucial for mRNA metabolism. While the mRNP proteome has been well …

Translation is a core cellular process carried out by a highly conserved macromolecular
machine, the ribosome. There has been remarkable evolutionary adaptation of this machine …

The budding yeast Saccharomyces cerevisiae must dynamically alter the composition of its
proteome in order to respond to diverse stresses. The reprogramming of gene expression …

Protein synthesis is metabolically costly and must be tightly coordinated with changing
cellular needs and nutrient availability. The cap-binding protein eIF4E makes the earliest …