Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …

Activation of purinoceptors by extracellular ATP is an important component of the glial
response to injury in the central nervous system (CNS). ATP has been shown to evoke …

ATP mediates fast excitatory synaptic transmission in some regions of the central nervous
system through activation of P2X receptors. Nonetheless, the functional significance of ATP …

A truncated naturally occurring variant of the human receptor P2X 7 was identified in cancer
cervical cells. The novel protein (P2X 7-j), a polypeptide of 258 amino acids, lacks the entire …

ATP has been shown to be an important extracellular signaling molecule. There are two
subgroups of receptors for ATP (and other purines and pyrimidines): the ionotropic P2X and …

The pyramidal neurons in the CA1 area of hippocampal slices from 17‐to 19‐day‐old rats
have been investigated by means of patch clamp. Excitatory postsynaptic currents (EPSCs) …

We investigated the expression of purinoceptors in human dendritic cells, providing
functional, pharmacological, and biochemical evidence that immature and mature cells …

Extracellular nucleotides are believed to be important regulators of ion transport in epithelial
tissues as a result of their ability to activate cell surface receptors. Although numerous …