Molecular targets of manganese-induced neurotoxicity: A five-year update

AA Tinkov, MMB Paoliello, AN Mazilina… - International journal of …, 2021 - mdpi.com
Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Emerging technologies and their impact on regulatory science

E Anklam, MI Bahl, R Ball, RD Beger… - Experimental …, 2022 - journals.sagepub.com
There is an evolution and increasing need for the utilization of emerging cellular, molecular
and in silico technologies and novel approaches for safety assessment of food, drugs, and …

[HTML][HTML] Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function

H Monsivais, CL Yeh, A Edmondson, R Harold… - NeuroImage, 2024 - Elsevier
Although manganese (Mn) is a trace metal essential for humans, chronic exposure to Mn
can cause accumulation of this metal ion in the brain leading to an increased risk of …

Manganese exposure and neurologic outcomes in adult populations

KV Martin, D Edmondson, KM Cecil… - Neurologic …, 2020 - neurologic.theclinics.com
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to Main Content Skip to Main Menu Advertisement Neurologic Clinics Log in Register Log in …

Whole-brain R1 predicts manganese exposure and biological effects in welders

DA Edmondson, CL Yeh, S Hélie, U Dydak - Archives of toxicology, 2020 - Springer
Manganese (Mn) is a neurotoxicant that, due to its paramagnetic property, also functions as
a magnetic resonance imaging (MRI) T1 contrast agent. Previous studies in Mn toxicity have …

[HTML][HTML] Welding techniques and manganese concentrations in blood and brain: Results from the WELDFUMES study

P Thunberg, G Wastensson, G Lidén, M Adjeiwaah… - Neurotoxicology, 2024 - Elsevier
This study used whole-brain mapping to investigate the effect of different welding processes
on manganese (Mn) accumulation in the brain. Exposure measurements were performed at …

Do toenail manganese and iron levels reflect brain metal levels or brain metabolism in welders?

G Nossa, H Monsivais, CG Lee, G Francis, EM Wells… - NeuroToxicology, 2024 - Elsevier
Inhalation of welding fumes can cause metal accumulation in the brain, leading to
Parkinsonian-like symptoms. Metal accumulation and altered neurochemical profiles have …

Magnetic resonance imaging T1 indices of the brain as biomarkers of inhaled manganese exposure

N Jensen, R Terrell, S Ramoju… - Critical Reviews in …, 2022 - Taylor & Francis
Excessive exposure to manganese (Mn) is linked to its accumulation in the brain and
adverse neurological effects. Paramagnetic properties of Mn allow the use of magnetic …

Diagnosis of manganism and manganese neurotoxicity: A workshop report

DR Mattison, F Momoli, C Alyanak… - Medicine …, 2024 - spandidos-publications.com
With declining exposures to manganese (Mn) in occupational settings, there is a need for
more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn …

Acquisition of Reproducible Edited MRS Data: Methods and Applications in Metal Neurotoxicity

G Nossa - 2024 - search.proquest.com
High exposure to manganese (Mn) through the inhalation of welding fumes has been shown
to have a toxic effect to the human brain, leading to parkinsonian-like symptoms such as …