Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne's Disease

G Rathnaiah, DK Zinniel, JP Bannantine… - Frontiers in veterinary …, 2017 - frontiersin.org
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's
disease in ruminants causing chronic diarrhea, malnutrition, and muscular wasting …

Repurposing of nucleoside-and nucleobase-derivative drugs as antibiotics and biofilm inhibitors

AEJ Yssel, J Vanderleyden… - Journal of Antimicrobial …, 2017 - academic.oup.com
There is an urgent need for new antibacterial drugs that are robust against the development
of resistance. Drug repurposing is a cost-effective strategy to fast-track the drug development …

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool …

D Antoniani, E Rossi, S Rinaldo, P Bocci… - Applied microbiology …, 2013 - Springer
In Gram-negative bacteria, production of the signal molecule c-di-GMP by diguanylate
cyclases (DGCs) is a key trigger for biofilm formation, which, in turn, is often required for the …

Profound remission in Crohn's disease requiring no further treatment for 3–23 years: a case series

G Agrawal, A Clancy, R Huynh, T Borody - Gut pathogens, 2020 - Springer
Background Crohn's disease (CD) is rising in incidence and has a high morbidity and
increased mortality. Current treatment use immunosuppressives but efficacy is suboptimal …

Cultivation of Mycobacterium avium subsp. paratuberculosis.

R Whittington - Paratuberculosis: organism, disease, control, 2020 - cabidigitallibrary.org
Paratuberculosis: organism, disease, control: Cultivation of <italic toggle='yes'>Mycobacterium
avium</italic&g Page 1 266 © CAB International 2020. Paratuberculosis: Organism, Disease …

[HTML][HTML] Significant antibacterial activity and synergistic effects of camel lactoferrin with antibiotics against methicillin-resistant Staphylococcus aureus (MRSA)

EM Redwan, N Abd El-Baky, AM Al-Hejin… - Research in …, 2016 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) causes major healthcare problems in
many countries, as it is present as several hospital-and community-associated strains …

Vitamins A & D inhibit the growth of mycobacteria in radiometric culture

RJ Greenstein, L Su, ST Brown - PloS one, 2012 - journals.plos.org
Background The role of vitamins in the combat of disease is usually conceptualized as
acting by modulating the immune response of an infected, eukaryotic host. We hypothesized …

Purine metabolism regulates Vibrio splendidus persistence associated with protein aggresome formation and intracellular tetracycline efflux

Y Li, TK Wood, W Zhang, C Li - Frontiers in Microbiology, 2023 - frontiersin.org
A small subpopulation of Vibrio splendidus AJ01 that was exposed to tetracycline at 10
times the minimal inhibitory concentration (MIC) still survived, named tetracycline-induced …

In-vitro drug release kinetics studies of mesoporous SBA-15-azathioprine composite

S Jangra, P Girotra, V Chhokar, VK Tomer… - Journal of Porous …, 2016 - Springer
The mesoporous silica (or SBA-15) was loaded with azathioprine drug. Azathioprine drug
was incorporated into mesoporous silica by post impregnation method to reduce its toxic …

Anti-mycobacterial antibiotic therapy induces remission in active pædiatric Crohn's disease

G Agrawal, H Hamblin, A Clancy, T Borody - Microorganisms, 2020 - mdpi.com
Crohn's disease is increasing in incidence and prevalence in younger people and is of a
particularly aggressive nature. One emerging treatment targets Mycobacterium avium …