There is an urgent need for new antibacterial drugs that are robust against the development of resistance. Drug repurposing is a cost-effective strategy to fast-track the drug development …
D Antoniani, E Rossi, S Rinaldo, P Bocci… - Applied microbiology …, 2013 - Springer
In Gram-negative bacteria, production of the signal molecule c-di-GMP by diguanylate cyclases (DGCs) is a key trigger for biofilm formation, which, in turn, is often required for the …
G Agrawal, A Clancy, R Huynh, T Borody - Gut pathogens, 2020 - Springer
Background Crohn's disease (CD) is rising in incidence and has a high morbidity and increased mortality. Current treatment use immunosuppressives but efficacy is suboptimal …
Methicillin-resistant Staphylococcus aureus (MRSA) causes major healthcare problems in many countries, as it is present as several hospital-and community-associated strains …
RJ Greenstein, L Su, ST Brown - PloS one, 2012 - journals.plos.org
Background The role of vitamins in the combat of disease is usually conceptualized as acting by modulating the immune response of an infected, eukaryotic host. We hypothesized …
Y Li, TK Wood, W Zhang, C Li - Frontiers in Microbiology, 2023 - frontiersin.org
A small subpopulation of Vibrio splendidus AJ01 that was exposed to tetracycline at 10 times the minimal inhibitory concentration (MIC) still survived, named tetracycline-induced …
The mesoporous silica (or SBA-15) was loaded with azathioprine drug. Azathioprine drug was incorporated into mesoporous silica by post impregnation method to reduce its toxic …
Crohn's disease is increasing in incidence and prevalence in younger people and is of a particularly aggressive nature. One emerging treatment targets Mycobacterium avium …