SLC7A11 reduces laser-induced choroidal neovascularization by inhibiting RPE ferroptosis and VEGF production

X Zhao, M Gao, J Liang, Y Chen, Y Wang… - Frontiers in cell and …, 2021 - frontiersin.org
In age-related macular degeneration (AMD), one of the principal sources of vascular
endothelial growth factor (VEGF) is retinal pigment epithelium (RPE) cells under hypoxia or …

Trolox aids coenzyme Q10 in neuroprotection against NMDA induced damage via upregulation of VEGF in rat model of glutamate excitotoxicity

S Upreti, TC Nag, MP Ghosh - Experimental Eye Research, 2024 - Elsevier
Glutamate induced damage to retinal ganglion cells (RGCs) requires tight physiological
regulation of the N-methyl-D-aspartate (NMDA) receptors. Previously, studies have …

Retinal degeneration in mice lacking the cyclic nucleotide‐gated channel subunit CNGA1

Y Liu, Y Wang, Y Xiao, X Li, S Ruan, X Luo… - The FASEB …, 2021 - Wiley Online Library
Cyclic nucleotide‐gated (CNG) channels are important mediators in the transduction
pathways of rod and cone photoreceptors. Native CNG channels are heterotetramers …

A novel and efficient murine model of Bietti crystalline dystrophy

Y Wang, Y Liu, S Liu, X Li, X Liu… - Disease Models & …, 2022 - journals.biologists.com
Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease,
resulting in blindness in most patients. The etiology and development mechanism of it …

Different effects of anti-VEGF drugs (Ranibizumab, Aflibercept, Conbercept) on autophagy and its effect on neovascularization in RF/6A cells

Y Wang, Y Yao, R Li, B Wu, H Lu, J Cheng, Z Liu… - Microvascular …, 2021 - Elsevier
Introduction Choroidal neovascularization (CNV) is the main pathological change of wet age-
related macular degeneration. Anti-VEGF drugs are the most commonly used treatment for …

[PDF][PDF] 褪黑素在糖尿病视网膜病变中的作用及机制

YKX Bao - cdn.amegroups.cn
糖尿病视网膜病变(diabetic retinopathy, DR) 是糖尿病引起的一种常见的微血管并发症,
是引起劳动年龄人群失明的主要原因. 氧化损伤是导致DR 发生的重要机制 …

[PDF][PDF] P53/DRAM/autophagy-a new target for improving the therapeutic effect of anti-VEGF on intraocular neovascularization

Y Wang, Y Yang, R Li, B Wu, H Lu, J Cheng, Z Liu, J Du - 2020 - scholar.archive.org
Methods RF/6A cells were randomly divided into ve groups: The control group, hypoxia
group (1% O25% CO2 94% N2), anti-VEGF group (group1: Ranibizumab 100ug/ml; group2 …

[引用][C] Gene-Based Approaches for Age-Related Macular Degeneration

JD Sengillo, J Sridhar - Gene, 2021