The role of fluoroquinolones in the treatment of tuberculosis in 2019

AD Pranger, TS Van Der Werf, JGW Kosterink… - Drugs, 2019 - Springer
The inability to use powerful antituberculosis drugs in an increasing number of patients
seems to be the biggest threat towards global tuberculosis (TB) elimination. Simplified …

Mental health disorders, social stressors, and health-related quality of life in patients with multidrug-resistant tuberculosis: a systematic review and meta-analysis

KA Alene, ACA Clements, ES McBryde, E Jaramillo… - Journal of Infection, 2018 - Elsevier
Background Mental health disorders, social stress, and poor health-related quality of life are
commonly reported among people with tuberculosis (TB). We conducted a systematic review …

9 months of delamanid, linezolid, levofloxacin, and pyrazinamide versus conventional therapy for treatment of fluoroquinolone-sensitive multidrug-resistant …

J Mok, M Lee, DK Kim, JS Kim, BW Jhun, KW Jo… - The Lancet, 2022 - thelancet.com
Background With the introduction of new anti-tuberculosis drugs, all-oral regimens with
shorter treatment durations for multidrug-resistant tuberculosis have been anticipated. We …

[HTML][HTML] Diagnosis and treatment of multidrug-resistant tuberculosis

JG Jang, JH Chung - Yeungnam University journal of …, 2020 - synapse.koreamed.org
Tuberculosis (TB) is still a major health problem worldwide. Especially, multidrug-resistant
TB (MDR-TB), which is defined as TB that shows resistance to both isoniazid and rifampicin …

Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations

J Sarathy, L Blanc, N Alvarez-Cabrera… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB)
treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB …

Final treatment outcomes of delamanid-containing regimens in patients with MDR-/XDR-TB in South Korea

J Mok, H Kang, WJ Koh, BW Jhun… - European …, 2019 - Eur Respiratory Soc
A phase III trial of delamanid showed acceptable safety and tolerability; however, it failed to
demonstrate superior efficacy of delamanid in terms of reduction in time to sputum …

Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis

YN White, BP Solans, P Denti… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Each year 25 000–32 000 children develop rifampicin-or multidrug-
resistant tuberculosis (RR/MDR-TB), and many more require preventive treatment …

[HTML][HTML] Nationwide treatment outcomes of patients with multidrug/rifampin-resistant tuberculosis in Korea, 2011–2017: a retrospective cohort study (Korean TB-POST)

H Choi, J Mok, YA Kang, D Jeong, HY Kang… - J Korean Med …, 2023 - synapse.koreamed.org
Background The treatment outcomes of patients with multidrug/rifampin-resistant (MDR/RR)
tuberculosis (TB) are important indicators that reflect the current status of TB management …

Current medical management of pulmonary tuberculosis

RW Belknap - Thoracic Surgery Clinics, 2019 - thoracic.theclinics.com
Tuberculosis (TB) has afflicted people for millennia and, unfortunately, despite effective
treatment was the leading cause of death from an infection in 2016, killing 1.7 million people …

Fluoroquinolones in drug-resistant tuberculosis: culture conversion and pharmacokinetic/pharmacodynamic target attainment to guide dose selection

MH Al-Shaer, WA Alghamdi, A Alsultan… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Fluoroquinolones are group A drugs in tuberculosis guidelines. We aim to compare the
culture conversion between new-generation (levofloxacin and moxifloxacin) and old …